OJ May Fight Inflammation, Oxidative Stress

Ernie NeffOrange Juice, Research

A new study suggests 100% orange juice (OJ) has the potential to help fight inflammation and oxidative stress in adults, paving the way for further research on the topic. Though limited in scope, the study indicates drinking 100% OJ significantly reduces interleukin 6, a well-established marker of inflammation, in both healthy and high-risk adults. Two additional inflammatory and oxidative stress markers were also reduced; however, the results did not quite reach statistical significance.

The findings of this study, funded through an unrestricted grant by the Florida Department of Citrus (FDOC), harmonize with a previously published FDOC-funded review. The previous review reported beneficial effects of hesperidin, the primary bioactive compound found in oranges and 100% OJ, on reducing some markers of inflammation and oxidative stress. Chronic inflammation may play a key role in causing or advancing some chronic diseases, including heart disease and diabetes.

The FDOC’s Scientific Research Department has used these results to outline the scope of work for a larger FDOC-sponsored clinical trial on the benefits of 100% OJ consumption expected to begin in late 2021.

 “We know that 100% orange juice contains a number of nutrients, like vitamin C, as well as beneficial bioactive compounds that have the potential to reduce inflammation and oxidative stress,” said Gail Rampersaud, FDOC registered dietitian. “This review tells us that some studies find benefits with 100% orange juice, but we need more data and large well-designed studies to make more definitive conclusions.”

The review, conducted by the Think Healthy Group and researchers at Tufts University and George Mason University, was published in the journal Advances in Nutrition.

The broad scoping and systematic reviews revealed that, in general, 100% OJ either had beneficial or null (no adverse) effects on oxidative stress or inflammation. The researchers cautioned that studies included a relatively small number of subjects, had a low strength of evidence and a moderate risk of bias. Therefore, overall findings should be interpreted with caution. 

Source: Florida Department of Citrus

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